INHBA

Across TCGA cell cohorts, INHBA mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible INHBA-associated genes across cancer lineages are GZMK, GJA10, and OR2K2. Each is linked with INHBA in more than 1 cancer types. Because this analysis shows association rather than direction, both INHBA-to-partner and partner-to-INHBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by INHBA-low versus INHBA-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INHBA→partner) and Y-score (partner→INHBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GZMK →	+0.004	+4.029	<.001	.007	3	1
PANCREAS	GJA10 →	+0.217	+3.786	<.001	.004	3	1
PANCREAS	OR2K2 →	+0.032	+4.222	<.001	.002	3	1
SKIN	RTL4 →	+0.006	+5.415	<.001	.004	3	1
SKIN	TXNDC8 →	+0.035	+4.977	<.001	.007	3	1
LUNG_SCLC	PIP →	+0.339	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GZMK by INHBA expression — PANCREAS

Explore this box plot interactively →