ING5

Across TCGA patient cohorts, ING5 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ING5-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ACC1. Each is linked with ING5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ING5-to-partner and partner-to-ING5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ING5-low versus ING5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ING5→partner) and Y-score (partner→ING5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.354	-3.807	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.162	-3.321	.002	.010	3	1
UCEC	ACC1 →	+0.421	+3.183	.010	.009	3	1
UCEC	JNK2 →	+0.317	+2.000	<.001	.032	3	1
UCEC	Ku80 →	+0.266	+2.013	.012	.018	3	1
UCEC	PDCD4 →	-0.616	-3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by ING5 expression — UCEC

Explore this box plot interactively →