ING3

Across TCGA patient cohorts, ING3 mutation is significantly associated with the RNA expression of many other genes, with 2,728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ING3-associated genes across cancer lineages are RRP36, ELP5, and CTDNEP1. Each is linked with ING3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ING3-to-partner and partner-to-ING3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RRP36 grouped by ING3-low versus ING3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ING3→partner) and Y-score (partner→ING3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RRP36 →	+0.461	+3.366	.009	.005	3	3
COAD	ELP5 →	+0.373	+3.519	.006	.002	3	3
COAD	CTDNEP1 →	+0.371	+2.713	.004	.003	3	3
COAD	TIMM22 →	+0.577	+3.820	<.001	<.001	3	3
COAD	TIMM21 →	+0.431	+2.713	.002	.003	3	3
UCEC	MBD1 →	+0.356	+2.137	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,728 associations by consensus.

RRP36 by ING3 expression — SKCM

Explore this box plot interactively →