ING2

Across TCGA patient cohorts, ING2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ING2-associated genes across cancer lineages are eIF4E, MEK1, and p62 Lck ligand. Each is linked with ING2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ING2-to-partner and partner-to-ING2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ING2-low versus ING2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ING2→partner) and Y-score (partner→ING2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.300	+3.000	.013	.036	2	1
UCEC	MEK1 →	+0.607	+3.000	.004	.037	1	1
UCEC	p62 Lck ligand →	+0.551	+3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

eIF4E by ING2 expression — UCEC

Explore this box plot interactively →