INCENP

Across TCGA pan-cancer cohorts, INCENP Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated INCENP data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INCENP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated INCENP expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, READ, and CESC are the cancer types where INCENP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.081	0.768	<.001	48	view →
READ	OS	Median	All	0.166	0.830	<.001	30	view →
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
KIRC	DFS	Median	II,III,IV	0.067	0.762	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.890	.012	12	view →
COAD	OS	Median	All	0.176	0.678	.011	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	II,III,IV	1.000	0.667	.018	5	view →
ESCA	DFS	Median	II,III,IV	0.205	0.527	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

INCENP–HNSC (OS)

Open the HNSC breakdown →