INCENP

Across TCGA pan-cancer cohorts, INCENP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INCENP data layer compared with 28 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher INCENP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated INCENP expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, LUAD, and OV are the cancer types where INCENP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.933	0.620	.003	16	view →
LUAD	DFS	Median	All	0.384	0.854	.009	5	view →
OV	DFS	Median	All	0.818	1.000	.020	4	view →
HNSC	OS	Median	All	0.452	1.000	.025	4	view →
GBM	DFS	Quartile	All	0.793	0.455	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INCENP–LSCC (DFS)

Open the LSCC breakdown →