INAVA

Across TCGA patient cohorts, INAVA protein abundance is significantly associated with the RNA expression of many other genes, with 3,015 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible INAVA-associated genes across cancer lineages are LCN2, IL1RAP, and GJB3. Each is linked with INAVA in more than 3 cancer types. Because this analysis shows association rather than direction, both INAVA-to-partner and partner-to-INAVA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INAVA versus LCN2 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INAVA→partner) and Y-score (partner→INAVA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LCN2 →	+2.786	+0.580	<.001	<.001	3	4
UCEC	IL1RAP →	+1.025	+1.287	<.001	.005	3	3
BRCA	GJB3 →	+1.554	+0.661	.006	.006	3	3
BRCA	ANXA8 →	+1.315	+0.817	<.001	<.001	3	3
BRCA	RARA →	-1.527	-0.647	.005	.008	3	2
BRCA	MAP3K21 →	+1.509	+0.995	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,015 associations by consensus.

INAVA vs LCN2 — LSCC

Explore this scatter interactively →