INAVA

Across TCGA patient cohorts, INAVA mutation is significantly associated with the RNA expression of many other genes, with 3,444 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible INAVA-associated genes across cancer lineages are GPX6, SRP14P2, and FAM200B. Each is linked with INAVA in more than 1 cancer types. Because this analysis shows association rather than direction, both INAVA-to-partner and partner-to-INAVA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX6 grouped by INAVA-low versus INAVA-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INAVA→partner) and Y-score (partner→INAVA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	GPX6 →	+0.153	+5.189	<.001	.006	3	2
SKCM	SRP14P2 →	+0.417	+1.919	<.001	.001	3	2
SKCM	FAM200B →	+0.421	+1.906	.002	.001	3	2
SKCM	MRPL33 →	+0.381	+1.893	.002	.001	3	2
SKCM	TTC4 →	+0.260	+2.675	.003	.004	3	2
CESC	RNU1-62P →	+0.192	+4.539	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,444 associations by consensus.

GPX6 by INAVA expression — SCLC

Explore this box plot interactively →