INAVA

Across TCGA patient cohorts, INAVA mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INAVA-associated genes across cancer lineages are eIF4E, eEF2, and MSH2. Each is linked with INAVA in more than 2 cancer types. Because this analysis shows association rather than direction, both INAVA-to-partner and partner-to-INAVA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by INAVA-low versus INAVA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INAVA→partner) and Y-score (partner→INAVA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.230	+2.807	.003	.003	3	3
UCEC	eEF2 →	+0.460	+3.700	<.001	.001	3	2
UCEC	MSH2 →	-0.203	-3.143	.019	.018	3	2
UCEC	PCNA →	+0.162	+1.807	.045	.025	3	2
UCEC	Shc_pY317 →	-0.148	-2.807	.009	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.657	+3.926	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by INAVA expression — UCEC

Explore this box plot interactively →