INAVA

Across TCGA cell cohorts, INAVA mutation is significantly associated with the RNA expression of many other genes, with 659 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INAVA-associated genes across cancer lineages are DEFB108B, KRTAP5-5, and MEIKIN. Each is linked with INAVA in more than 1 cancer types. Because this analysis shows association rather than direction, both INAVA-to-partner and partner-to-INAVA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108B grouped by INAVA-low versus INAVA-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INAVA→partner) and Y-score (partner→INAVA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DEFB108B →	+0.080	+5.000	<.001	.005	3	1
KIDNEY	KRTAP5-5 →	+0.020	+5.000	<.001	.005	3	1
SKIN	MEIKIN →	+0.022	+5.415	<.001	.004	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.017	+5.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 659 associations by consensus.

DEFB108B by INAVA expression — KIDNEY

Explore this box plot interactively →