INA

Across TCGA pan-cancer cohorts, INA Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated INA data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher INA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated INA expression acts as an unfavorable survival marker, although some lineages such as COAD and LUSC show a favorable association.

LUAD, COAD, and LUSC are the cancer types where INA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.265	0.562	.045	6	view →
COAD	DFS	Median	All	1.000	0.677	.018	5	view →
LUSC	DFS	Median	All	1.000	0.366	.024	4	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

INA–LUAD (OS)

Open the LUAD breakdown →