INA

Across TCGA patient cohorts, INA mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INA-associated genes across cancer lineages are A-Raf_pS299, 14-3-3_beta, and Bax. Each is linked with INA in more than 1 cancer types. Because this analysis shows association rather than direction, both INA-to-partner and partner-to-INA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by INA-low versus INA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INA→partner) and Y-score (partner→INA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.185	-3.321	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.113	-3.295	.006	.009	3	2
UCEC	Bax →	+0.233	+2.321	.018	.006	3	2
UCEC	C-Raf →	+0.203	+3.584	<.001	.002	3	2
COAD	Bcl-2 →	+0.307	+3.008	.031	.019	3	1
UCEC	eEF2 →	+0.454	+2.321	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

A-Raf_pS299 by INA expression — UCEC

Explore this box plot interactively →