IMPG2

Across TCGA patient cohorts, IMPG2 mutation is significantly associated with the RNA expression of many other genes, with 6,591 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPG2-associated genes across cancer lineages are SNRPD3, RFC5, and DTYMK. Each is linked with IMPG2 in more than 5 cancer types. Because this analysis shows association rather than direction, both IMPG2-to-partner and partner-to-IMPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD3 grouped by IMPG2-low versus IMPG2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPG2→partner) and Y-score (partner→IMPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRPD3 →	+0.429	+2.713	<.001	.003	3	6
UCEC	RFC5 →	+0.537	+2.747	<.001	<.001	3	6
UCEC	DTYMK →	+0.537	+2.108	<.001	<.001	3	6
UCEC	POLE →	+0.455	+2.145	<.001	<.001	3	6
BLCA	XRCC2 →	+0.725	+2.722	<.001	.003	3	6
UCEC	DBF4B →	+0.493	+1.830	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,591 associations by consensus.

SNRPD3 by IMPG2 expression — COAD

Explore this box plot interactively →