IMPG2

Across TCGA patient cohorts, IMPG2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPG2-associated genes across cancer lineages are Cyclin-B1, FoxM1, and 4E-BP1. Each is linked with IMPG2 in more than 4 cancer types. Because this analysis shows association rather than direction, both IMPG2-to-partner and partner-to-IMPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by IMPG2-low versus IMPG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPG2→partner) and Y-score (partner→IMPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.685	+2.050	<.001	<.001	3	5
BLCA	FoxM1 →	+0.327	+2.459	.001	.020	3	4
SKCM	4E-BP1 →	+0.367	+2.321	.005	.032	3	4
UCEC	p62 Lck ligand →	+0.409	+2.321	<.001	<.001	3	3
COAD	ASNS →	+0.905	+3.459	<.001	.005	3	3
UCEC	Shc_pY317 →	-0.183	-1.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Cyclin-B1 by IMPG2 expression — UCEC

Explore this box plot interactively →