IMPG2

Across TCGA cell cohorts, IMPG2 mutation is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMPG2-associated genes across cancer lineages are BPIFB6, NXPH2, and OR8D1. Each is linked with IMPG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPG2-to-partner and partner-to-IMPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by IMPG2-low versus IMPG2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPG2→partner) and Y-score (partner→IMPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	2
OESOPHAGUS	NXPH2 →	+0.017	+2.847	<.001	.004	3	1
OESOPHAGUS	OR8D1 →	+0.044	+2.906	<.001	.004	3	1
OESOPHAGUS	PAPOLB →	+0.028	+3.158	<.001	.001	3	1
OESOPHAGUS	RFPL4AL1 →	+0.191	+2.874	.003	.009	3	1
BLOOD_Myeloma	CNGA3 →	+0.036	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

BPIFB6 by IMPG2 expression — BLOOD_Leukemia

Explore this box plot interactively →