IMPG1

Across TCGA patient cohorts, IMPG1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPG1-associated genes across cancer lineages are NF-kB-p65_pS536, p38-MAPK_pT180_Y182, and PKC-b-II_pS660. Each is linked with IMPG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IMPG1-to-partner and partner-to-IMPG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by IMPG1-low versus IMPG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPG1→partner) and Y-score (partner→IMPG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF-kB-p65_pS536 →	-0.382	-2.000	.015	.029	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.456	-1.723	.003	.007	3	3
UCEC	PKC-b-II_pS660 →	-0.270	-1.906	.004	.015	3	3
UCEC	c-Met_pY1235 →	+0.066	+1.736	.009	.007	3	3
UCEC	Cyclin-B1 →	+0.535	+1.736	.006	.007	3	3
LUSC	YAP_pS127 →	-0.294	-3.798	.037	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

NF-kB-p65_pS536 by IMPG1 expression — UCEC

Explore this box plot interactively →