IMPG1

Across TCGA cell cohorts, IMPG1 mutation is significantly associated with the RNA expression of many other genes, with 336 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMPG1-associated genes across cancer lineages are MOGS, LY6G6F, and OR4S1. Each is linked with IMPG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPG1-to-partner and partner-to-IMPG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MOGS grouped by IMPG1-low versus IMPG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPG1→partner) and Y-score (partner→IMPG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MOGS →	+0.434	+2.502	.003	.005	3	2
LUNG_NSCLC_LUSC	LY6G6F →	+0.036	+4.643	<.001	.008	3	1
LUNG_SCLC	OR4S1 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	RTP2 →	+0.021	+5.169	<.001	<.001	3	1
LARGE_INTESTINE	GCAT →	+1.041	+3.169	.006	.009	3	1
LARGE_INTESTINE	COCH →	+2.181	+3.321	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 336 associations by consensus.

MOGS by IMPG1 expression — LARGE_INTESTINE

Explore this box plot interactively →