IMPDH2

Across TCGA pan-cancer cohorts, IMPDH2 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IMPDH2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where IMPDH2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IMPDH2 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where IMPDH2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IMPDH2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.569	<.001	12	view →
HNSC	All	All	−0.449	<.001	12	view →
COAD	Female	III,IV	+0.410	<.001	10	view →
LUAD	Male	III,IV	+0.427	<.001	9	view →
LSCC	Male	All	+0.657	<.001	8	view →
PDAC	Female	All	−0.564	<.001	8	view →
OV	All	All	+0.328	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IMPDH2–CCRCC

Open the CCRCC breakdown →