IMPDH2

Across TCGA patient cohorts, IMPDH2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPDH2-associated genes across cancer lineages are ATM, C-Raf, and INPP4B. Each is linked with IMPDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPDH2-to-partner and partner-to-IMPDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by IMPDH2-low versus IMPDH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH2→partner) and Y-score (partner→IMPDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.513	-2.321	.015	.034	3	2
UCEC	C-Raf →	+0.206	+2.321	.002	.034	3	2
UCEC	INPP4B →	-0.300	-2.999	.046	.035	3	1
UCEC	Ku80 →	+0.264	+2.598	.016	.006	3	1
UCEC	PDK1_pS241 →	+0.168	+3.321	.034	.010	3	1
UCEC	AMPK_pT172 →	+0.534	+2.598	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ATM by IMPDH2 expression — UCEC

Explore this box plot interactively →