IMPDH2

Across TCGA cell cohorts, IMPDH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,832 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible IMPDH2-associated GO terms across cancer lineages are Response to unfolded protein, 'de novo' IMP biosynthetic process, and AMP biosynthetic process. Each is linked with IMPDH2 in more than 14 cancer types. Because this analysis shows association rather than direction, both IMPDH2-to-partner and partner-to-IMPDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to unfolded protein grouped by IMPDH2-low versus IMPDH2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH2→partner) and Y-score (partner→IMPDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Response to unfolded protein →	-0.087	-1.030	<.001	<.001	3	15
URINARY_TRACT	'de novo' IMP biosynthetic process →	+0.181	+0.897	<.001	<.001	3	14
LIVER	AMP biosynthetic process →	+0.138	+0.669	<.001	.001	3	14
LUNG_NSCLC_LUSC	Protein import into mitochondrial intermembrane space →	+0.118	+0.673	<.001	.006	3	13
BONE	tRNA C3-cytosine methylation →	+0.141	+0.827	<.001	.002	3	13
URINARY_TRACT	XMP metabolic process →	+0.139	+0.825	.001	.002	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,832 associations by consensus.

Response to unfolded protein by IMPDH2 expression — OESOPHAGUS

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