IMPDH1

Across TCGA patient cohorts, IMPDH1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,014 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IMPDH1-associated genes across cancer lineages are RNF5, MMP9, and TGFB1. Each is linked with IMPDH1 in more than 6 cancer types. Because this analysis shows association rather than direction, both IMPDH1-to-partner and partner-to-IMPDH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IMPDH1 versus RNF5 in OV, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH1→partner) and Y-score (partner→IMPDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNF5 →	-0.607	-0.316	.006	<.001	3	7
GBM	MMP9 →	+2.253	+0.429	<.001	<.001	3	5
LUAD	TGFB1 →	+0.606	+0.249	.001	.003	3	5
BRCA	SEPSECS →	-0.436	-0.269	<.001	<.001	3	5
BRCA	PRKAB1 →	-0.697	-0.397	<.001	<.001	3	5
LUAD	ANLN →	+1.145	+0.257	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,014 associations by consensus.

IMPDH1 vs RNF5 — OV

Explore this scatter interactively →