IMPDH1

Across TCGA patient cohorts, IMPDH1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPDH1-associated genes across cancer lineages are Rab25, EGFR_pY1068, and eIF4E. Each is linked with IMPDH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPDH1-to-partner and partner-to-IMPDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by IMPDH1-low versus IMPDH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH1→partner) and Y-score (partner→IMPDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.378	-2.415	.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.253	-1.584	.005	.019	3	1
UCEC	eIF4E →	+0.178	+2.807	.019	.003	3	1
UCEC	A-Raf_pS299 →	-0.132	-3.459	.002	.005	3	1
UCEC	ERK2 →	+0.209	+2.321	.002	.001	3	1
UCEC	JNK2 →	+0.173	+1.884	.015	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Rab25 by IMPDH1 expression — UCEC

Explore this box plot interactively →