IMPDH1

Across TCGA cell cohorts, IMPDH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,709 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IMPDH1-associated GO terms across cancer lineages are XMP metabolic process, XMP biosynthetic process, and 'de novo' XMP biosynthetic process. Each is linked with IMPDH1 in more than 17 cancer types. Because this analysis shows association rather than direction, both IMPDH1-to-partner and partner-to-IMPDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XMP metabolic process grouped by IMPDH1-low versus IMPDH1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH1→partner) and Y-score (partner→IMPDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	XMP metabolic process →	+0.209	+1.234	.002	.002	3	18
OESOPHAGUS	XMP biosynthetic process →	+0.209	+1.234	.002	.002	3	18
OESOPHAGUS	'de novo' XMP biosynthetic process →	+0.209	+1.234	.002	.002	3	18
OESOPHAGUS	GMP biosynthetic process →	+0.173	+1.144	.005	.005	3	15
OVARY	Purine ribonucleoside monophosphate biosynthetic process →	+0.111	+1.057	.002	.002	2	13
BONE	rRNA transcription →	+0.145	+1.384	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,709 associations by consensus.

XMP metabolic process by IMPDH1 expression — OESOPHAGUS

Explore this box plot interactively →