IMPDH1

Across TCGA cell cohorts, IMPDH1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMPDH1-associated genes across cancer lineages are OR2AT4, ACTL7A, and PPP3R2. Each is linked with IMPDH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPDH1-to-partner and partner-to-IMPDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AT4 grouped by IMPDH1-low versus IMPDH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH1→partner) and Y-score (partner→IMPDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2AT4 →	+0.018	+4.196	.001	.002	3	1
LARGE_INTESTINE	ACTL7A →	+0.024	+3.823	.001	.006	3	1
LARGE_INTESTINE	PPP3R2 →	+0.055	+3.884	<.001	.005	3	1
LARGE_INTESTINE	NYX →	+0.051	+4.347	.003	.001	3	1
LARGE_INTESTINE	OR2J1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR2AT4 by IMPDH1 expression — LARGE_INTESTINE

Explore this box plot interactively →