IMPACT

Across TCGA patient cohorts, IMPACT mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPACT-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and MEK1. Each is linked with IMPACT in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPACT-to-partner and partner-to-IMPACT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IMPACT-low versus IMPACT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPACT→partner) and Y-score (partner→IMPACT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.329	-3.584	.006	.002	3	1
UCEC	eIF4E →	+0.201	+3.169	.048	.019	3	1
UCEC	MEK1 →	+0.492	+3.584	.005	.002	3	1
UCEC	Myosin-IIa_pS1943 →	+0.215	+3.000	.031	.036	3	1
UCEC	Myosin-IIa →	+0.203	+2.466	.023	.011	3	1
UCEC	Notch1 →	+0.252	+3.013	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by IMPACT expression — UCEC

Explore this box plot interactively →