IMPACT

Across TCGA cell cohorts, IMPACT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,341 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IMPACT-associated GO terms across cancer lineages are GCN2-mediated signaling, Regulation of cytoplasmic translational initiation, and Regulation of translation in response to stress. Each is linked with IMPACT in more than 14 cancer types. Because this analysis shows association rather than direction, both IMPACT-to-partner and partner-to-IMPACT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCN2-mediated signaling grouped by IMPACT-low versus IMPACT-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPACT→partner) and Y-score (partner→IMPACT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GCN2-mediated signaling →	+0.202	+0.996	<.001	<.001	3	15
LARGE_INTESTINE	Regulation of cytoplasmic translational initiation →	+0.140	+1.005	<.001	.008	3	13
OESOPHAGUS	Regulation of translation in response to stress →	+0.080	+0.810	.008	<.001	3	10
SKIN	Endosomal transport →	+0.051	+0.537	<.001	.003	3	8
LARGE_INTESTINE	Golgi vesicle transport →	+0.050	+1.042	.001	.005	2	9
UPPER_AERODIGESTIVE_TRACT	Regulation of Golgi inheritance →	+0.155	+0.901	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,341 associations by consensus.

GCN2-mediated signaling by IMPACT expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →