IMPACT

Across TCGA cell cohorts, IMPACT mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMPACT-associated genes across cancer lineages are C6orf118, MYH8, and DEFA4. Each is linked with IMPACT in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPACT-to-partner and partner-to-IMPACT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by IMPACT-low versus IMPACT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPACT→partner) and Y-score (partner→IMPACT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.104	+3.793	.005	.007	3	1
LARGE_INTESTINE	MYH8 →	+0.092	+3.920	<.001	.005	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C6orf118 by IMPACT expression — LARGE_INTESTINE

Explore this box plot interactively →