IMPACT

Across TCGA cell cohorts, IMPACT mutation is significantly associated with the mutation status of many other genes, with 1,310 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMPACT-associated genes across cancer lineages are DDHD1, BPNT2, and COQ6. Each is linked with IMPACT in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPACT-to-partner and partner-to-IMPACT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDHD1 grouped by IMPACT-low versus IMPACT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPACT→partner) and Y-score (partner→IMPACT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DDHD1 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	BPNT2 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	COQ6 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	TACO1 →	+4.329	+4.329	.001	.001	1	2
LARGE_INTESTINE	SNX27 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	RABL3 →	+5.329	+4.672	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,310 associations by consensus.

DDHD1 by IMPACT expression — LARGE_INTESTINE

Explore this box plot interactively →