IMPA2

Across TCGA patient cohorts, IMPA2 protein abundance is significantly associated with the protein abundance of many other proteins, with 23,554 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible IMPA2-associated proteins across cancer lineages are VCAN, HK2, and ELMO2. Each is linked with IMPA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both IMPA2-to-partner and partner-to-IMPA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IMPA2 versus VCAN in LSCC, with a Pearson correlation of -0.40.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPA2→partner) and Y-score (partner→IMPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VCAN →	-0.980	-0.653	<.001	<.001	3	6
LSCC	HK2 →	+0.532	+0.793	<.001	<.001	3	5
COAD	ELMO2 →	-0.302	-0.804	<.001	<.001	2	6
LSCC	AFG3L2 →	+0.482	+0.605	<.001	<.001	3	5
BRCA	POLE3 →	+0.494	+1.023	<.001	<.001	3	5
BRCA	PTPN2 →	+0.344	+0.691	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,554 associations by consensus.

IMPA2 vs VCAN — LSCC

Explore this scatter interactively →