IMPA2

Across TCGA patient cohorts, IMPA2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPA2-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and GAPDH. Each is linked with IMPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPA2-to-partner and partner-to-IMPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IMPA2-low versus IMPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPA2→partner) and Y-score (partner→IMPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.077	-2.432	.046	.018	3	1
UCEC	eIF4E →	+0.218	+3.472	.006	.002	3	1
UCEC	GAPDH →	+0.537	+3.459	.009	.005	3	1
UCEC	GATA6 →	-0.136	-1.670	.021	.022	3	1
UCEC	ACC1 →	+0.328	+2.183	.018	.033	3	1
UCEC	HSP70 →	-0.387	-3.575	.011	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by IMPA2 expression — UCEC

Explore this box plot interactively →