IMPA2

Across TCGA cell cohorts, IMPA2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMPA2-associated genes across cancer lineages are TMCO5A, GPR171, and CCL18. Each is linked with IMPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPA2-to-partner and partner-to-IMPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by IMPA2-low versus IMPA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPA2→partner) and Y-score (partner→IMPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GPR171 →	+0.019	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TMCO5A by IMPA2 expression — LARGE_INTESTINE

Explore this box plot interactively →