IMPA1

Across TCGA patient cohorts, IMPA1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPA1-associated genes across cancer lineages are ASNS, EGFR, and A-Raf_pS299. Each is linked with IMPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPA1-to-partner and partner-to-IMPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by IMPA1-low versus IMPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPA1→partner) and Y-score (partner→IMPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.683	+3.584	<.001	.002	3	2
UCEC	EGFR →	-0.232	-1.700	<.001	.044	3	1
UCEC	A-Raf_pS299 →	-0.148	-2.321	.003	.034	3	1
UCEC	FoxM1 →	+0.339	+4.000	.001	<.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.535	+1.700	.013	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-3.321	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASNS by IMPA1 expression — UCEC

Explore this box plot interactively →