IMPA1

Across TCGA cell cohorts, IMPA1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMPA1-associated genes across cancer lineages are SCGB1C2, KCNK17, and KIR2DS4. Each is linked with IMPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPA1-to-partner and partner-to-IMPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C2 grouped by IMPA1-low versus IMPA1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPA1→partner) and Y-score (partner→IMPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCGB1C2 →	+0.306	+5.029	<.001	.006	3	1
LARGE_INTESTINE	KCNK17 →	+0.066	+3.466	<.001	.009	3	1
LARGE_INTESTINE	KIR2DS4 →	+0.007	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SCGB1C2 by IMPA1 expression — LUNG_SCLC

Explore this box plot interactively →