IMP4

Across TCGA patient cohorts, IMP4 mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMP4-associated genes across cancer lineages are RPS6P20, RNA5SP502, and EIF3JP1. Each is linked with IMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMP4-to-partner and partner-to-IMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS6P20 grouped by IMP4-low versus IMP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMP4→partner) and Y-score (partner→IMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS6P20 →	+0.073	+1.791	.006	.009	3	2
UCEC	RNA5SP502 →	+0.699	+2.119	<.001	.006	3	2
UCEC	EIF3JP1 →	+0.176	+2.231	<.001	.004	3	2
LUSC	MIR1268B →	+0.829	+4.447	<.001	.006	3	2
COAD	MIR4418 →	+0.713	+4.308	<.001	.009	3	2
STAD	PRR20E →	+0.016	+4.824	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

RPS6P20 by IMP4 expression — UCEC

Explore this box plot interactively →