IMP4

Across TCGA patient cohorts, IMP4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMP4-associated genes across cancer lineages are MEK1, Heregulin, and p62 Lck ligand. Each is linked with IMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMP4-to-partner and partner-to-IMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by IMP4-low versus IMP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMP4→partner) and Y-score (partner→IMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.348	+3.169	.049	.019	3	2
UCEC	Heregulin →	-0.149	-3.584	.012	.002	3	1
UCEC	p62 Lck ligand →	+0.424	+2.459	.007	.020	3	1
UCEC	Cyclin-B1 →	+0.721	+3.584	.007	.002	3	1
UCEC	14-3-3_beta →	-0.117	-2.446	.015	.020	2	1
UCEC	Caspase-8 →	-0.327	-3.584	.007	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by IMP4 expression — UCEC

Explore this box plot interactively →