IMMT

Across TCGA patient cohorts, IMMT protein abundance is significantly associated with the RNA expression of many other genes, with 18,542 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IMMT-associated genes across cancer lineages are GIMAP6, GAS1, and NECAB3. Each is linked with IMMT in more than 6 cancer types. Because this analysis shows association rather than direction, both IMMT-to-partner and partner-to-IMMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IMMT versus GIMAP6 in OV, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMMT→partner) and Y-score (partner→IMMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GIMAP6 →	-0.680	-0.225	.006	.002	3	7
COAD	GAS1 →	-1.543	-0.252	<.001	<.001	3	7
BRCA	NECAB3 →	+0.655	+0.176	.009	.005	3	6
UCEC	CNRIP1 →	-0.728	-0.381	.004	<.001	3	6
OV	POSTN →	-2.311	-0.289	.003	<.001	3	6
GBM	LUM →	-1.589	-0.223	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,542 associations by consensus.

IMMT vs GIMAP6 — OV

Explore this scatter interactively →