IMMT

Across TCGA cell cohorts, IMMT mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IMMT-associated genes across cancer lineages are PHOX2B, DCSTAMP, and IL25. Each is linked with IMMT in more than 1 cancer types. Because this analysis shows association rather than direction, both IMMT-to-partner and partner-to-IMMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by IMMT-low versus IMMT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMMT→partner) and Y-score (partner→IMMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHOX2B →	+0.021	+3.921	.007	.001	3	1
LARGE_INTESTINE	DCSTAMP →	+0.109	+2.936	.001	.007	3	1
LARGE_INTESTINE	IL25 →	+0.040	+3.562	<.001	.002	3	1
LARGE_INTESTINE	TRIM49B →	+0.232	+3.217	<.001	.006	3	1
LARGE_INTESTINE	OR4A47 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR5M11 →	+0.119	+3.417	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PHOX2B by IMMT expression — LARGE_INTESTINE

Explore this box plot interactively →