Across TCGA patient cohorts, ILRUN mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ILRUN-associated genes across cancer lineages are EGFR_pY1068, ERK2, and JNK_pT183_Y185. Each is linked with ILRUN in more than 1 cancer types. Because this analysis shows association rather than direction, both ILRUN-to-partner and partner-to-ILRUN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ILRUN→partner) and Y-score (partner→ILRUN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.337	-2.459	.005	.019	3	1
UCEC	ERK2 →	+0.245	+2.459	.008	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.209	-3.000	.010	.036	3	1
UCEC	Ku80 →	+0.317	+2.472	.005	.011	3	1
UCEC	MAPK_pT202_Y204 →	-0.479	-3.000	.035	.036	3	1
UCEC	p70-S6K_pT389 →	-0.240	-2.459	.009	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

ILRUN survival (RNA) · tumor vs normal (RNA) · all ILRUN data types