ILDR2

Across TCGA patient cohorts, ILDR2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ILDR2-associated genes across cancer lineages are c-Met_pY1235, FOXO3a_pS318_S321, and GSK-3_pS9. Each is linked with ILDR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ILDR2-to-partner and partner-to-ILDR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by ILDR2-low versus ILDR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ILDR2→partner) and Y-score (partner→ILDR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.075	+2.469	.014	.010	3	3
UCEC	FOXO3a_pS318_S321 →	-0.150	-2.797	.003	.003	3	2
UCEC	GSK-3_pS9 →	-0.500	-2.115	.002	.017	3	2
UCEC	MEK1 →	+0.399	+2.459	.008	.019	3	2
UCEC	MIG-6 →	+0.109	+3.013	.007	<.001	3	2
UCEC	PCNA →	+0.296	+4.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

c-Met_pY1235 by ILDR2 expression — UCEC

Explore this box plot interactively →