IL7

Across TCGA patient cohorts, IL7 mutation is significantly associated with the RNA expression of many other genes, with 1,171 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL7-associated genes across cancer lineages are RNA5SP386, DCTPP1, and EMC3-AS1. Each is linked with IL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL7-to-partner and partner-to-IL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP386 grouped by IL7-low versus IL7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL7→partner) and Y-score (partner→IL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP386 →	+0.335	+2.613	<.001	.007	3	2
UCEC	DCTPP1 →	+0.797	+3.711	.001	<.001	3	2
UCEC	EMC3-AS1 →	+0.603	+3.191	.002	.009	3	2
UCEC	FANCA →	+0.771	+3.343	<.001	.005	3	2
UCEC	ZNF511 →	+0.590	+3.700	<.001	.001	3	2
UCEC	PRDX2P2 →	+0.183	+3.188	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,171 associations by consensus.

RNA5SP386 by IL7 expression — UCEC

Explore this box plot interactively →