IL7

Across TCGA cell cohorts, IL7 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL7-associated genes across cancer lineages are PF4V1 and IFNG. Each is linked with IL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL7-to-partner and partner-to-IL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PF4V1 grouped by IL7-low versus IL7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL7→partner) and Y-score (partner→IL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PF4V1 →	+0.294	+3.793	<.001	.007	3	1
LARGE_INTESTINE	IFNG →	+0.010	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PF4V1 by IL7 expression — LARGE_INTESTINE

Explore this box plot interactively →