Across TCGA pan-cancer cohorts, IL6STP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IL6STP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IL6STP1 RNA is repressed in tumor relative to normal tissue. In most cancer types IL6STP1 is over-expressed in tumor, although a few such as LUSC and ESCA show the opposite, repressed pattern.

LUSC, ESCA, and THCA are the cancer types where IL6STP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL6STP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.155	<.001	6	view →
ESCA	All	II,III,IV	−0.375	.019	3	view →
THCA	All	All	−0.110	.001	3	view →
KICH	Female	All	−0.183	.042	2	view →
PAAD	All	All	−0.125	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IL6STP1 RNA expression & survival · all IL6STP1 data types