IL6

Across TCGA patient cohorts, IL6 RNA expression is significantly associated with the RNA expression of many other genes, with 13,736 significant associations in total. UVM shows the largest number of these associations.

The most reproducible IL6-associated genes across cancer lineages are SOCS3, SNAI1, and SLC2A3. Each is linked with IL6 in more than 32 cancer types. Because this analysis shows association rather than direction, both IL6-to-partner and partner-to-IL6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL6 versus SOCS3 in PCPG, with a Pearson correlation of 0.81.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6→partner) and Y-score (partner→IL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PCPG	SOCS3 →	+2.777	+2.295	<.001	<.001	3	33
PCPG	SNAI1 →	+2.052	+2.244	<.001	<.001	3	33
BLCA	SLC2A3 →	+1.671	+2.295	<.001	<.001	3	33
DLBC	IL10 →	+2.660	+2.430	<.001	<.001	2	33
PCPG	ADAMTS4 →	+2.241	+2.027	<.001	<.001	3	32
MESO	CD93 →	+1.468	+2.817	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,736 associations by consensus.

IL6 vs SOCS3 — PCPG

Explore this scatter interactively →