IL6

Across TCGA patient cohorts, IL6 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,540 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IL6-associated proteins across cancer lineages are PROS1, C4BPB, and FGA. Each is linked with IL6 in more than 9 cancer types. Because this analysis shows association rather than direction, both IL6-to-partner and partner-to-IL6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL6 versus PROS1 in COAD, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6→partner) and Y-score (partner→IL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PROS1 →	+0.767	+1.079	<.001	.002	3	10
GBM	C4BPB →	+1.055	+2.050	<.001	<.001	3	10
OV	FGA →	+0.816	+1.131	<.001	<.001	3	10
OV	FGB →	+0.841	+1.151	<.001	<.001	3	10
LSCC	C3 →	+0.554	+1.699	<.001	<.001	3	9
COAD	C4BPA →	+0.995	+1.122	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,540 associations by consensus.

IL6 vs PROS1 — COAD

Explore this scatter interactively →