IL6

Across TCGA patient cohorts, IL6 protein abundance is significantly associated with the RNA expression of many other genes, with 639 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IL6-associated genes across cancer lineages are IGHG4, EHD4, and DMPK. Each is linked with IL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL6-to-partner and partner-to-IL6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL6 versus IGHG4 in LSCC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6→partner) and Y-score (partner→IL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGHG4 →	+2.692	+0.713	.001	.007	3	2
HNSC	EHD4 →	+0.620	+1.604	.001	.004	3	1
HNSC	DMPK →	-1.453	-1.656	.007	.001	3	1
HNSC	MYH1 →	-4.506	-1.656	.003	.001	3	1
HNSC	FHL5 →	-1.727	-1.656	.005	.001	3	1
HNSC	CCNG1 →	-0.702	-1.656	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 639 associations by consensus.

IL6 vs IGHG4 — LSCC

Explore this scatter interactively →