IL6

Across TCGA patient cohorts, IL6 mutation is significantly associated with the RNA expression of many other genes, with 1,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL6-associated genes across cancer lineages are TUBB1P2, MIR6784, and VN1R25P. Each is linked with IL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL6-to-partner and partner-to-IL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB1P2 grouped by IL6-low versus IL6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6→partner) and Y-score (partner→IL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TUBB1P2 →	+0.050	+8.741	<.001	<.001	3	3
UCEC	MIR6784 →	+0.634	+1.776	.005	.009	3	2
HNSC	VN1R25P →	+0.200	+5.182	<.001	.007	3	2
HNSC	RBISP1 →	+0.185	+5.505	<.001	.004	3	2
HNSC	SNRPGP8 →	+0.215	+5.578	<.001	.004	3	2
HNSC	RNU6-1308P →	+0.434	+6.608	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,435 associations by consensus.

TUBB1P2 by IL6 expression — COAD

Explore this box plot interactively →