IL6

Across TCGA cell cohorts, IL6 RNA expression is significantly associated with the RNA expression of many other genes, with 8,747 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IL6-associated genes across cancer lineages are CCN1, NNMT, and SOCS3. Each is linked with IL6 in more than 13 cancer types. Because this analysis shows association rather than direction, both IL6-to-partner and partner-to-IL6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL6 versus CCN1 in BONE, with a Pearson correlation of 0.59.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6→partner) and Y-score (partner→IL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CCN1 →	+4.375	+2.260	<.001	.001	3	14
BONE	NNMT →	+6.149	+3.241	<.001	<.001	3	14
BONE	SOCS3 →	+2.986	+3.197	<.001	<.001	3	13
BONE	INHBA →	+3.049	+2.989	<.001	.001	3	13
BONE	TICAM2 →	+2.831	+3.885	<.001	<.001	3	12
BONE	GLIPR1 →	+4.569	+3.242	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,747 associations by consensus.

IL6 vs CCN1 — BONE

Explore this scatter interactively →