IL5RA

Across TCGA patient cohorts, IL5RA mutation is significantly associated with the RNA expression of many other genes, with 2,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL5RA-associated genes across cancer lineages are RNU6-1323P, KPNA2, and GET3. Each is linked with IL5RA in more than 2 cancer types. Because this analysis shows association rather than direction, both IL5RA-to-partner and partner-to-IL5RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1323P grouped by IL5RA-low versus IL5RA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL5RA→partner) and Y-score (partner→IL5RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1323P →	+0.085	+4.924	<.001	.002	3	3
UCEC	KPNA2 →	+0.663	+2.917	.001	<.001	3	3
UCEC	GET3 →	+0.395	+1.546	.002	.009	3	3
UCEC	WDHD1 →	+0.560	+1.872	.001	.004	3	3
UCEC	E2F1 →	+1.015	+2.534	<.001	<.001	3	3
UCEC	ZWINT →	+0.568	+2.081	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,457 associations by consensus.

RNU6-1323P by IL5RA expression — LUAD

Explore this box plot interactively →