IL5RA

Across TCGA cell cohorts, IL5RA mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL5RA-associated genes across cancer lineages are FAM47A, CCL25, and AKAIN1. Each is linked with IL5RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL5RA-to-partner and partner-to-IL5RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47A grouped by IL5RA-low versus IL5RA-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL5RA→partner) and Y-score (partner→IL5RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FAM47A →	+0.029	+3.700	<.001	.005	3	1
SKIN	CCL25 →	+0.055	+4.095	.004	.009	3	1
SKIN	AKAIN1 →	+0.071	+4.930	<.001	.001	3	1
SKIN	USP17L17 →	+0.010	+5.022	<.001	.002	3	1
LARGE_INTESTINE	ASPN →	+0.030	+4.011	.008	<.001	3	1
LARGE_INTESTINE	GBE1 →	+0.685	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

FAM47A by IL5RA expression — OVARY

Explore this box plot interactively →