IL5

Across TCGA patient cohorts, IL5 protein abundance is significantly associated with the RNA expression of many other genes, with 1,780 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IL5-associated genes across cancer lineages are SOSTDC1, NR1D2, and PTCH1. Each is linked with IL5 in more than 3 cancer types. Because this analysis shows association rather than direction, both IL5-to-partner and partner-to-IL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL5 versus SOSTDC1 in BRCA, with a Pearson correlation of 0.89.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL5→partner) and Y-score (partner→IL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SOSTDC1 →	+3.569	+1.499	<.001	.002	3	4
LSCC	NR1D2 →	+0.494	+1.439	.007	.001	3	2
LSCC	PTCH1 →	+1.080	+1.208	<.001	.006	3	2
LSCC	PSPC1P1 →	+1.778	+1.318	<.001	.001	3	2
HNSC	ZHX2 →	+1.061	+1.463	.001	.007	3	2
HNSC	RTN3P1 →	+1.842	+1.609	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,780 associations by consensus.

IL5 vs SOSTDC1 — BRCA

Explore this scatter interactively →